タイトル | Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 20, Page 1821-1824, Year 2010 |
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掲載日 | 2009年12月22日 (構造データの登録日) |
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著者 | McLean, L.R. / Zhang, Y. / Li, H. / Choi, Y.M. / Han, Z. / Vaz, R.J. / Li, Y. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:20185308 |
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手法 | X線回折 |
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解像度 | 1.7 - 1.94 Å |
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構造データ | PDB-3l5p: Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyridazinol inhibitor at 1.80A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3l5r: Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-3l5s: Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyrimidinylphenyl inhibitor at 1.86A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-3l5t: Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-3l5u: Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3l5v: Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å |
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化合物 | ChemComp-428: 2-(1-methylethyl)imidazo[1,2-b]pyridazin-6-ol
ChemComp-88X: 5-ethyl-2-(phenylcarbonyl)imidazo[1,2-a]pyrimidin-7(1H)-one
ChemComp-956: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile
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由来 | homo sapiens (ヒト)
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キーワード | ISOMERASE / PROTEIN-LIGAND COMPLEX / CYTOKINE / CYTOPLASM / IMMUNE RESPONSE / INFLAMMATORY RESPONSE / INNATE IMMUNITY / PHOSPHOPROTEIN / SECRETED / Acetylation |
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