Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
PDB-3jt3: Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[2-(methylsulfanyl)ethanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å
PDB-3jt4: Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[(3-(ethylsulfanyl)propanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
PDB-3jt5: Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[2-(ethylsulfanyl)ethanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
PDB-3jt6: Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[4-(methylsulfanyl)butanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
PDB-3jt7: Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[2-(propylsulfanyl)ethanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
PDB-3jt8: Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-{3-[(1-methylethyl)sulfanyl]propanimidoyl}-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å
PDB-3jt9: Structure of neuronal nitric oxide synthase heme domain in the ferrous state complexed with N~5~-[2-(ethylsulfanyl)ethanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
PDB-3jta: Structure of neuronal nitric oxide synthase heme domain in the ferrous state complexed with N~5~-[4-(methylsulfanyl)butanimidoyl]-L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å