タイトル | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 132, Page 1359-1370, Year 2010 |
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掲載日 | 2009年8月11日 (構造データの登録日) |
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著者 | Choi, S. / Reixach, N. / Connelly, S. / Johnson, S.M. / Wilson, I.A. / Kelly, J.W. |
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リンク | J. Am. Chem. Soc. / PubMed:20043671 |
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手法 | X線回折 |
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解像度 | 1.31 - 1.7 Å |
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構造データ | PDB-3imr: Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3ims: Transthyretin in complex with 2,6-dibromo-4-(2,6-dichlorophenethyl)phenol 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-3imt: Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromophenol 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-3imu: Transthyretin in complex with (E)-4-(3-aminostyryl)-2,6-dibromoaniline 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-3imv: Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromoaniline 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-3imw: Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dimethoxystyryl)aniline 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å |
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化合物 | ChemComp-IW1: 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol
ChemComp-IW2: 2,6-dibromo-4-[2-(2,6-dichlorophenyl)ethyl]phenol
ChemComp-IW4: 4-[(E)-2-(3-aminophenyl)ethenyl]-2,6-dibromoaniline
ChemComp-IW5: 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromoaniline
ChemComp-IW6: 2,6-dibromo-4-[(E)-2-(2,6-dimethoxyphenyl)ethenyl]aniline
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由来 | homo sapiens (ヒト)
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キーワード | HORMONE / Growth Factor / Amyloid / Disease mutation / Gamma-carboxyglutamic acid / Glycoprotein / Polymorphism / Polyneuropathy / Retinol-binding / Secreted / Thyroid hormone / Transport / Vitamin A |
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