タイトル | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives |
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ジャーナル・号・ページ | Biochemistry, Vol. 48, Page 8594-8602, Year 2009 |
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掲載日 | 2009年8月4日 (構造データの登録日) |
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著者 | Ptak, C.P. / Ahmed, A.H. / Oswald, R.E. |
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リンク | Biochemistry / PubMed:19673491 |
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手法 | X線回折 |
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解像度 | 1.998 - 2.881 Å |
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構造データ | PDB-3ijo: Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide 手法: X-RAY DIFFRACTION / 解像度: 2.003 Å PDB-3ijx: Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide 手法: X-RAY DIFFRACTION / 解像度: 2.881 Å PDB-3ik6: Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide 手法: X-RAY DIFFRACTION / 解像度: 2.101 Å PDB-3il1: Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 手法: X-RAY DIFFRACTION / 解像度: 1.998 Å PDB-3ilt: Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide 手法: X-RAY DIFFRACTION / 解像度: 2.107 Å PDB-3ilu: Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide 手法: X-RAY DIFFRACTION / 解像度: 2.003 Å |
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化合物 | ChemComp-B4D: (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
ChemComp-HCZ: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide / ヒドロクロロチアジド / 薬剤*YM
ChemComp-TRU: 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
ChemComp-HFZ: 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide / ヒドロフルメチアジド
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由来 | - rattus norvegicus (ドブネズミ)
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キーワード | MEMBRANE PROTEIN / glutamate receptor / glur2 / AMPA receptor / neurotransmitter receptor / S1S2 / allosteric modulator / Alternative splicing / Cell junction / Cell membrane / Endoplasmic reticulum / Glycoprotein / Ion transport / Ionic channel / Lipoprotein / Membrane / Palmitate / Phosphoprotein / Postsynaptic cell membrane / Receptor / RNA editing / Synapse / Transmembrane / Transport / SIGNALING PROTEIN |
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