タイトル | Structural studies of pterin-based inhibitors of dihydropteroate synthase. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 53, Page 166-177, Year 2010 |
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掲載日 | 2009年4月14日 (構造データの登録日) |
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著者 | Hevener, K.E. / Yun, M.K. / Qi, J. / Kerr, I.D. / Babaoglu, K. / Hurdle, J.G. / Balakrishna, K. / White, S.W. / Lee, R.E. |
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リンク | J. Med. Chem. / PubMed:19899766 |
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手法 | X線回折 |
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解像度 | 2 - 2.7 Å |
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構造データ | PDB-3h21: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.32 Å PDB-3h22: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-3h23: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3h24: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3h26: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3h2a: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-3h2c: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-3h2e: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-3h2f: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3h2m: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-3h2n: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-3h2o: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å |
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化合物 | ChemComp-B52: (2R)-2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid
ChemComp-B54: 4-{3-[(2-amino-5-nitroso-6-oxo-1,6-dihydropyrimidin-4-yl)amino]propoxy}benzoic acid
ChemComp-B56: 2-amino-8-methyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carboxylic acid
ChemComp-B59: 1,3-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropteridine-6-carbaldehyde
ChemComp-B60: 2-amino-8-methyl-7,8-dihydropteridin-4(3H)-one
ChemComp-B61: 2-amino-6-(2-hydroxy-2-methylpropyl)-8-methyl-7,8-dihydropteridin-4(3H)-one
ChemComp-B63: 4-{[2-(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)ethyl]amino}benzoic acid
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由来 | - bacillus anthracis str. a2012 (炭疽菌)
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キーワード | Transferase/Transferase Inhibitor / ANTHRACIS / FOLATE BIOSYNTHESIS / DIHYDROPTEROATE / PTERINE / Transferase / Transferase-Transferase Inhibitor COMPLEX |
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