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-Structure paper
タイトル | Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 53, Page 573-585, Year 2010 |
掲載日 | 2008年12月8日 (構造データの登録日) |
![]() | Sandanayaka, V. / Mamat, B. / Mishra, R.K. / Winger, J. / Krohn, M. / Zhou, L.M. / Keyvan, M. / Enache, L. / Sullins, D. / Onua, E. ...Sandanayaka, V. / Mamat, B. / Mishra, R.K. / Winger, J. / Krohn, M. / Zhou, L.M. / Keyvan, M. / Enache, L. / Sullins, D. / Onua, E. / Zhang, J. / Halldorsdottir, G. / Sigthorsdottir, H. / Thorlaksdottir, A. / Sigthorsson, G. / Thorsteinnsdottir, M. / Davies, D.R. / Stewart, L.J. / Zembower, D.E. / Andresson, T. / Kiselyov, A.S. / Singh, J. / Gurney, M.E. |
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手法 | X線回折 |
解像度 | 1.63 - 2.39 Å |
構造データ | ![]() PDB-3fh5: ![]() PDB-3fh7: ![]() PDB-3fh8: ![]() PDB-3fhe: ![]() PDB-3ftz: ![]() PDB-3ful: |
化合物 | ![]() ChemComp-ZN: ![]() ChemComp-YB: ![]() ChemComp-ACT: ![]() ChemComp-IMD: ![]() ChemComp-24P: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-25P: ![]() ChemComp-27P: ![]() ChemComp-28P: ![]() ChemComp-848: ![]() ChemComp-52D: |
由来 |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / LTA4H / Leukotriene A4 / Leukotriene B4 Biosynthesis / Peptidase / Hydrolase-hydrolase inhibitor complex / Structure Based Drug Design / Leukotriene biosynthesis / Metal-binding / Metalloprotease / Multifunctional enzyme / Protease / Leukotriene A4 Hydrolase / Fragment crystallography / Fragments of Life / FOL |