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-Structure paper
タイトル | Design, synthesis, and biological evaluation of potent c-Met inhibitors. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 51, Page 5766-5779, Year 2008 |
掲載日 | 2008年9月9日 (構造データの登録日) |
![]() | D'Angelo, N.D. / Bellon, S.F. / Booker, S.K. / Cheng, Y. / Coxon, A. / Dominguez, C. / Fellows, I. / Hoffman, D. / Hungate, R. / Kaplan-Lefko, P. ...D'Angelo, N.D. / Bellon, S.F. / Booker, S.K. / Cheng, Y. / Coxon, A. / Dominguez, C. / Fellows, I. / Hoffman, D. / Hungate, R. / Kaplan-Lefko, P. / Lee, M.R. / Li, C. / Liu, L. / Rainbeau, E. / Reider, P.J. / Rex, K. / Siegmund, A. / Sun, Y. / Tasker, A.S. / Xi, N. / Xu, S. / Yang, Y. / Zhang, Y. / Burgess, T.L. / Dussault, I. / Kim, T.S. |
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手法 | X線回折 |
解像度 | 2.2 - 2.6 Å |
構造データ | ![]() PDB-3efj: ![]() PDB-3efk: |
化合物 | ![]() ChemComp-MT3: ![]() ChemComp-HOH: ![]() ChemComp-MT4: |
由来 |
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![]() | TRANSFERASE / c-Met / Alternative splicing / ATP-binding / Chromosomal rearrangement / Disease mutation / Glycoprotein / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Proto-oncogene / Receptor / Transmembrane / Tyrosine-protein kinase / Kinase inhibitor pyrimidone |