タイトル New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine ジャーナル・号・ページ J. Med. Chem. , Vol. 52, Page 1388-1407, Year 2009掲載日 2008年7月29日 (構造データの登録日) 著者McCloskey, D.E. / Bale, S. / Secrist III, J.A. / Tiwari, A. / Moss III, T.H. / Valiyaveettil, J. / Brooks, W.H. / Guida, W.C. / Pegg, A.E. / Ealick, S.E. リンク J. Med. Chem. / PubMed:19209891手法 X線回折 解像度 1.83 - 2.62 Å 構造データ PDB-3dz2 : 構造ビューア Human AdoMetDC with 5'-[(3-aminopropyl)methylamino]-5'deoxy-8-methyladenosine 手法 : X-RAY DIFFRACTION / 解像度 : 1.86 Å
PDB-3dz3 : 構造ビューア Human AdoMetDC F223A mutant with covalently bound S-Adenosylmethionine methyl ester 手法 : X-RAY DIFFRACTION / 解像度 : 2.62 Å
PDB-3dz4 : 構造ビューア Human AdoMetDC with 5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine 手法 : X-RAY DIFFRACTION / 解像度 : 1.84 Å
PDB-3dz5 : 構造ビューア Human AdoMetDC with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine 手法 : X-RAY DIFFRACTION / 解像度 : 2.43 Å
PDB-3dz6 : 構造ビューア Human AdoMetDC with 5'-[(4-aminooxybutyl)methylamino]-5'deoxy-8-ethyladenosine 手法 : X-RAY DIFFRACTION / 解像度 : 1.83 Å
PDB-3dz7 : 構造ビューア Human AdoMetDC with 5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine 手法 : X-RAY DIFFRACTION / 解像度 : 1.91 Å
化合物 ChemComp-A8M : 構造ビューア 5'-[(3-aminopropyl)(methyl)amino]-5'-deoxy-8-methyladenosine
ChemComp-C8M : 構造ビューア 3-[{[(2R,3S,4R,5R)-5-(6-amino-8-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)amino]propanamid
ChemComp-M8E : 構造ビューア 5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine
ChemComp-O8M : 構造ビューア 2-[{[(2R,3S,4R,5R)-5-(6-amino-8-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)amino]acetamide
由来 homo sapiens (ヒト) キーワード LYASE / Complexes of AdoMetDC with 8-substituted ligands / Decarboxylase / Pyruvate / S-adenosyl-L-methionine / Spermidine biosynthesis / Zymogen / LIGASE