タイトル | Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 51, Page 5000-5008, Year 2008 |
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掲載日 | 2008年6月27日 (構造データの登録日) |
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著者 | Ren, J. / Chamberlain, P.P. / Stamp, A. / Short, S.A. / Weaver, K.L. / Romines, K.R. / Hazen, R. / Freeman, A. / Ferris, R.G. / Andrews, C.W. ...Ren, J. / Chamberlain, P.P. / Stamp, A. / Short, S.A. / Weaver, K.L. / Romines, K.R. / Hazen, R. / Freeman, A. / Ferris, R.G. / Andrews, C.W. / Boone, L. / Chan, J.H. / Stammers, D.K. |
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リンク | J. Med. Chem. / PubMed:18665583 |
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手法 | X線回折 |
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解像度 | 2.2 - 3.1 Å |
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構造データ | PDB-3dle: Crystal structure of hiv-1 reverse transcriptase in complex with GF128590. 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3dlg: Crystal structure of hiv-1 reverse transcriptase in complex with GW564511. 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3dm2: Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with GW564511. 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-3dmj: CRYSTAL STRUCTURE OF HIV-1 V106A and Y181C MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH GW564511. 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-3dok: Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248. 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-3dol: Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with GW695634. 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-GWE: N-{4-[amino(dihydroxy)-lambda~4~-sulfanyl]-2-methylphenyl}-2-(4-chloro-2-{[3-fluoro-5-(trifluoromethyl)phenyl]carbonyl}phenoxy)acetamide
ChemComp-GWJ: 2-{4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenoxy}-N-(2-methyl-4-sulfamoylphenyl)acetamide / GW-8248
ChemComp-GWI: N-({4-[({4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenoxy}acetyl)amino]-3-methylphenyl}sulfonyl)propanamide / GW-695634
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由来 | - hiv-1 m:b_hxb2r (ヒト免疫不全ウイルス)
- human immunodeficiency virus type 1 (ヒト免疫不全ウイルス)
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キーワード | TRANSFERASE / HIV-1 REVERSE TRANSCRIPTASE / AIDS / NNRTI / GF128590 / DRUG RESISTANCE / Hydrolase / GW564511 / K103N mutation / GW678248 / GW695634 |
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