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-Structure paper
タイトル | Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 19, Page 1177-1182, Year 2009 |
掲載日 | 2008年6月4日 (構造データの登録日) |
著者 | Thomson, S.A. / Banker, P. / Bickett, D.M. / Boucheron, J.A. / Carter, H.L. / Clancy, D.C. / Cooper, J.P. / Dickerson, S.H. / Garrido, D.M. / Nolte, R.T. ...Thomson, S.A. / Banker, P. / Bickett, D.M. / Boucheron, J.A. / Carter, H.L. / Clancy, D.C. / Cooper, J.P. / Dickerson, S.H. / Garrido, D.M. / Nolte, R.T. / Peat, A.J. / Sheckler, L.R. / Sparks, S.M. / Tavares, F.X. / Wang, L. / Wang, T.Y. / Weiel, J.E. |
リンク | Bioorg. Med. Chem. Lett. / PubMed:19138846 |
手法 | X線回折 |
解像度 | 1.8 - 2.57 Å |
構造データ | PDB-3dd1: PDB-3dds: PDB-3ddw: |
化合物 | ChemComp-NBG: ChemComp-PLP: ChemComp-CFF: ChemComp-25D: ChemComp-MPD: ChemComp-MES: ChemComp-HOH: ChemComp-PO4: ChemComp-26B: ChemComp-055: |
由来 |
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キーワード | TRANSFERASE / Glycogen Phosphorylase HLGP / Diabetes / Allosteric enzyme / Carbohydrate metabolism / Disease mutation / Glycogen metabolism / Glycogen storage disease / Glycosyltransferase / Nucleotide-binding / Phosphoprotein / Pyridoxal phosphate / GP / Glycogen Phosphorylase |