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-Structure paper
タイトル | Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 18, Page 4181-4185, Year 2008 |
掲載日 | 2008年5月7日 (構造データの登録日) |
![]() | Kim, S.H. / Tran, M.T. / Ruebsam, F. / Xiang, A.X. / Ayida, B. / McGuire, H. / Ellis, D. / Blazel, J. / Tran, C.V. / Murphy, D.E. ...Kim, S.H. / Tran, M.T. / Ruebsam, F. / Xiang, A.X. / Ayida, B. / McGuire, H. / Ellis, D. / Blazel, J. / Tran, C.V. / Murphy, D.E. / Webber, S.E. / Zhou, Y. / Shah, A.M. / Tsan, M. / Showalter, R.E. / Patel, R. / Gobbi, A. / LeBrun, L.A. / Bartkowski, D.M. / Nolan, T.G. / Norris, D.A. / Sergeeva, M.V. / Kirkovsky, L. / Zhao, Q. / Han, Q. / Kissinger, C.R. |
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手法 | X線回折 |
解像度 | 2.2 - 2.3 Å |
構造データ | ![]() PDB-3d28: ![]() PDB-3d5m: |
化合物 | ![]() ChemComp-B34: ![]() ChemComp-HOH: ![]() ChemComp-4MS: |
由来 |
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![]() | TRANSFERASE / Protein-Ligand Complex / RNA-DIRECTED RNA POLYMERASE / NUCLEOTIDYLTRANSFERASE / NUCLEOTIDE-BINDING / TRANSCRIPTION / HYDROLASE / RNA POLYMERASE / RNA REPLICATION / RNA-BINDING |