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-Structure paper
タイトル | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. |
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ジャーナル・号・ページ | Proteins, Vol. 73, Page 889-901, Year 2008 |
掲載日 | 2006年5月19日 (構造データの登録日) |
著者 | Schormann, N. / Senkovich, O. / Walker, K. / Wright, D.L. / Anderson, A.C. / Rosowsky, A. / Ananthan, S. / Shinkre, B. / Velu, S. / Chattopadhyay, D. |
リンク | Proteins / PubMed:18536013 |
手法 | X線回折 |
解像度 | 2.4 - 3.3 Å |
構造データ | PDB-2h2q: PDB-3cl9: PDB-3clb: |
化合物 | ChemComp-NAP: ChemComp-DU: ChemComp-HOH: ChemComp-SO4: ChemComp-CL: ChemComp-MTX: ChemComp-UMP: ChemComp-EDO: ChemComp-TMQ: |
由来 |
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キーワード | OXIDOREDUCTASE / TRANSFERASE / Bifunctional enzyme in complex with NADP and dUMP / Bifunctional Enzyme in Complex with NADP / MTX and DUMP / Methyltransferase / Multifunctional enzyme / Nucleotide biosynthesis / One-carbon metabolism / OXIDOREDUCTASE-TRANSFERASE COMPLEX / Bifunctional Enzyme in Complex with NADP and TMQ |