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-Structure paper
タイトル | Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 18, Page 2990-2995, Year 2008 |
掲載日 | 2008年3月12日 (構造データの登録日) |
著者 | Antonysamy, S.S. / Aubol, B. / Blaney, J. / Browner, M.F. / Giannetti, A.M. / Harris, S.F. / Hebert, N. / Hendle, J. / Hopkins, S. / Jefferson, E. ...Antonysamy, S.S. / Aubol, B. / Blaney, J. / Browner, M.F. / Giannetti, A.M. / Harris, S.F. / Hebert, N. / Hendle, J. / Hopkins, S. / Jefferson, E. / Kissinger, C. / Leveque, V. / Marciano, D. / McGee, E. / Najera, I. / Nolan, B. / Tomimoto, M. / Torres, E. / Wright, T. |
リンク | Bioorg. Med. Chem. Lett. / PubMed:18400495 |
手法 | X線回折 |
解像度 | 1.75 - 2.07 Å |
構造データ | PDB-3ciz: PDB-3cj0: PDB-3cj2: PDB-3cj3: PDB-3cj4: PDB-3cj5: |
化合物 | ChemComp-ZN: ChemComp-SX1: ChemComp-HOH: ChemComp-SX2: ChemComp-NI: ChemComp-SX3: ChemComp-SX4: ChemComp-SX5: ChemComp-SX6: |
由来 |
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キーワード | TRANSFERASE / DRUG DISCOVERY / HCV NS5B / FRAGMENT BASED / Apoptosis / ATP-binding / Capsid protein / Endoplasmic reticulum / Envelope protein / Fusion protein / Glycoprotein / Helicase / Host-virus interaction / Hydrolase / Interferon antiviral system evasion / Lipid droplet / Lipoprotein / Membrane / Metal-binding / Mitochondrion / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Nucleus / Oncogene / Palmitate / Phosphoprotein / Protease / Ribonucleoprotein / RNA replication / RNA-binding / RNA-directed RNA polymerase / Secreted / Serine protease / SH3-binding / Thiol protease / Transcription / Transcription regulation / Transmembrane / Viral nucleoprotein / Virion / Acetylation / Cytoplasm / Ubl conjugation / Zinc |