EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Mechanism of action and inhibition of dehydrosqualene synthase
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 107, Page 21337-21342, Year 2010
掲載日	2010年1月13日 (構造データの登録日)
著者	Lin, F.Y. / Liu, C.I. / Liu, Y.L. / Zhang, Y. / Wang, K. / Jeng, W.Y. / Ko, T.P. / Cao, R. / Wang, A.H.J. / Oldfield, E.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:21098670
手法	X線回折
解像度	1.31 - 2.85 Å
構造データ	PDB-3acw: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-651 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-3acx: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å PDB-3acy: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-702 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-3adz: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-3ae0: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with geranylgeranyl thiopyrophosphate 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å PDB-3lgz: Crystal structure of dehydrosqualene synthase Y129A from S. aureus complexed with presqualene pyrophosphate 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-3npr: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from S. aureus complexed with Presqualene diphosphate (PSPP) 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3nri: Crystal structure of the C(30) carotenoid dehydrosqualene synthase from S. aureus complexed with dehydrosqualene (DHS) 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å
化合物	ChemComp-651: (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol ChemComp-HOH: WATER / 水 ChemComp-673: N-(1-methylethyl)-3-[(3-prop-2-en-1-ylbiphenyl-4-yl)oxy]propan-1-amine / N-イソプロピル-3-(3-アリル-4-ビフェニリルオキシ)-1-プロパンアミン ChemComp-702: (1R)-4-[3-(2-benzylphenoxy)phenyl]-1-phosphonobutane-1-sulfonic acid ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-PS7: {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate / 二りん酸α-[[(1R)-2α-[(3E)-4,8-ジメチル-3,7-ノナジエニル]-2-メチル-3α-[(1E,5E(以下略) ChemComp-GGS: phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid ChemComp-DH7: (6E,10R,13S,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,11,13,14,18,22-octaene
由来	staphylococcus aureus (黄色ブドウ球菌)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / CrtM / Carotenoid biosynthesis / Staphyloxanthin biosynthesis / Transferase (転移酵素) / Head-to-head condensation / Inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / Intermediate / Geranylgeranyl thiopyrophosphate / GGsPP / C30 carotenoid / virulence factor (病原性因子) / presqualene diphosphate / PSPP / dehydrosqualene synthase / carotenoid (カロテノイド) / terpene (テルペン) / DHS / prenyl transferase (プレニル基転移酵素)