タイトル | Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates |
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ジャーナル・号・ページ | To be Published |
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掲載日 | 2008年8月7日 (構造データの登録日) |
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著者 | Nitanai, Y. / Shimamura, T. / Uchiyama, T. / Ishii, Y. / Takehira, M. / Yutani, K. / Matsuzawa, H. / Miyano, M. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 0.95 - 1.19 Å |
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構造データ | PDB-2zq9: Cephalothin acyl-intermediate structure of class a beta-lactamase Toho-1 E166A/R274N/R276N triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.07 Å PDB-2zqa: Cefotaxime acyl-intermediate structure of class a beta-lacta Toho-1 E166A/R274N/R276N triple mutant 手法: X-RAY DIFFRACTION / 解像度: 0.95 Å PDB-2zqc: Aztreonam acyl-intermediate structure of class a beta-lactam Toho-1 E166A/R274N/R276N triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.07 Å PDB-2zqd: Ceftazidime acyl-intermediate structure of class a beta-lact Toho-1 E166A/R274N/R276N triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.19 Å |
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化合物 | ChemComp-CEO: 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID
ChemComp-CEF: CEFOTAXIME, C3' cleaved, open, bound form / 抗生剤*YM
ChemComp-AZR: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid / 抗生剤*YM
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由来 | ![](img/tx_bacteria.gif) escherichia coli (大腸菌)
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キーワード | HYDROLASE / EXTENDED-SPECTRUM / ESBL / BETA-LACTAMASE / ACYL-ENZYME / COMPLEX / CEPHALOTHIN / TOHO-1 / Antibiotic resistance / Plasmid / CEFOTAXIME / ACYL-ENZYME COMPLEX / AZTREONAM / CEFTAZIDIME |
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