タイトル | Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 385, Page 188-199, Year 2009 |
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掲載日 | 2008年3月12日 (構造データの登録日) |
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著者 | Waku, T. / Shiraki, T. / Oyama, T. / Fujimoto, Y. / Maebara, K. / Kamiya, N. / Jingami, H. / Morikawa, K. |
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リンク | J. Mol. Biol. / PubMed:18977231 |
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手法 | X線回折 |
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解像度 | 2.26 - 2.61 Å |
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構造データ | PDB-2zk0: Human peroxisome proliferator-activated receptor gamma ligand binding domain 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-2zk1: Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-2zk2: Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with glutathion conjugated 15-deoxy-delta12,14-prostaglandin J2 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-2zk3: Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 8-oxo-eicosatetraenoic acid 手法: X-RAY DIFFRACTION / 解像度: 2.58 Å PDB-2zk4: Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo-eicosatetraenoic acid 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-2zk5: Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with nitro-233 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å |
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化合物 | ChemComp-PTG: (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
ChemComp-OCX: (5E,11E,14E)-8-oxoicosa-5,9,11,14-tetraenoic acid
ChemComp-OCR: (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid
ChemComp-NRO: 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSCRIPTION / anti parallel helix sandwich / Activator / Alternative splicing / Diabetes mellitus / Disease mutation / DNA-binding / Metal-binding / Nucleus / Obesity / Phosphoprotein / Polymorphism / Receptor / Transcription regulation / Zinc / Zinc-finger |
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