EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
ジャーナル・号・ページ	J. Med. Chem., Vol. 51, Page 5594-5607, Year 2008
掲載日	2007年6月26日 (構造データの登録日)
著者	Chen, C.K.-M. / Hudock, M.P. / Zhang, Y. / Guo, R.-T. / Cao, R. / No, J.H. / Liang, P.-H. / Ko, T.-P. / Chang, T.-H. / Chang, S.-C. ...Chen, C.K.-M. / Hudock, M.P. / Zhang, Y. / Guo, R.-T. / Cao, R. / No, J.H. / Liang, P.-H. / Ko, T.-P. / Chang, T.-H. / Chang, S.-C. / Song, Y. / Axelson, J. / Kumar, A. / Wang, A.H.-J. / Oldfield, E.
リンク	J. Med. Chem. / PubMed:18800762
手法	X線回折
解像度	1.86 - 2.45 Å
構造データ	PDB-2z4v: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site) 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-2z4w: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-749 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-2z4x: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252 (P21) 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2z4y: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2z4z: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-sc01 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-2z50: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-28 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-2z52: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-23 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-2z78: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2z7i: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-742 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-GRG: GERANYLGERANYL DIPHOSPHATE / ゲラニルゲラニルピロりん酸 ChemComp-HOH: WATER ChemComp-749: [(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid) ChemComp-252: (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) / 1-ヒドロキシノニリデンビスホスホン酸 ChemComp-SC0: (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID) ChemComp-028: (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) / 1-ヒドロキシヘプチリデンビスホスホン酸 ChemComp-H23: (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID) / 1-(ヒドロキシ)ドデシリデンビスホスホン酸 ChemComp-H86: 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium ChemComp-742: (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM
由来	saccharomyces cerevisiae (パン酵母)
キーワード	TRANSFERASE / prenyltransferase / geranylgeranyl pyrophosphate / bisphosphonate / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex / Carotenoid biosynthesis / Isoprene biosynthesis / Multifunctional enzyme / Protein transport / Transport