タイトル | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. |
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ジャーナル・号・ページ | J. Struct. Biol., Vol. 176, Page 292-, Year 2011 |
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掲載日 | 2010年7月7日 (構造データの登録日) |
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著者 | Lountos, G.T. / Jobson, A.G. / Tropea, J.E. / Self, C.R. / Zhang, G. / Pommier, Y. / Shoemaker, R.H. / Waugh, D.S. |
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リンク | J. Struct. Biol. / PubMed:21963792 |
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手法 | X線回折 |
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解像度 | 1.77 - 2.35 Å |
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構造データ | PDB-2xk9: Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-2ycf: Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-2ycq: Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-2ycr: Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2ycs: Crystal structure of checkpoint kinase 2 in complex with PV788 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å |
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化合物 | ChemComp-XK9: N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide
ChemComp-YCF: (2E)-N-hydroxy-2-[1-(4-{[(4-{(1E)-1-[2-(N'-hydroxycarbamimidoyl)hydrazinylidene]ethyl}phenyl)carbamoyl]amino}phenyl)ethylidene]hydrazinecarboximidamide
ChemComp-UPX: N-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE
ChemComp-HCW: 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA
ChemComp-NXP: N-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / STRUCTURE-BASED DRUG DESIGN / ANTICANCER / ANTICANCER DRUG DESIGN |
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