タイトル | Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 20, Page 6483-, Year 2010 |
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掲載日 | 2010年8月25日 (構造データの登録日) |
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著者 | Potter, A. / Oldfield, V. / Nunns, C. / Fromont, C. / Ray, S. / Northfield, C.J. / Bryant, C.J. / Scrace, S.F. / Robinson, D. / Matossova, N. ...Potter, A. / Oldfield, V. / Nunns, C. / Fromont, C. / Ray, S. / Northfield, C.J. / Bryant, C.J. / Scrace, S.F. / Robinson, D. / Matossova, N. / Baker, L. / Dokurno, P. / Surgenor, A.E. / Davis, B. / Richardson, C.M. / Murray, J.B. / Moore, J.D. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:20932746 |
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手法 | X線回折 |
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解像度 | 1.8 - 2.3 Å |
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構造データ | PDB-2xp3: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2xp4: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2xp5: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xp6: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xp7: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2xp8: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2xp9: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xpa: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xpb: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3odk: Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å |
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化合物 | ChemComp-12P: DODECAETHYLENE GLYCOL / 3,6,9,12,15,18,21,24,27,30,33-ウンデカオキサペンタトリアコンタン-1,35-ジオ-ル / 沈殿剤*YM
ChemComp-4G2: 2-(3-CHLORO-PHENYL)-5-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID
ChemComp-4FY: 4-(MORPHOLIN-4-YLCARBONYL)-2-PHENYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID
ChemComp-4G8: 4-[BENZYL(CARBOXYMETHYL)CARBAMOYL]-2-PHENYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID
ChemComp-4G5: 4-[(2-amino-2-oxoethyl)(methyl)carbamoyl]-2-phenyl-1H-imidazole-5-carboxylic acid
ChemComp-4GE: 5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID
ChemComp-ODK: 3-pyridin-2-yl-1H-pyrazole-5-carboxylic acid
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由来 | - homo sapiens (ヒト)
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キーワード | ISOMERASE / PROLINE DIRECTED KINASE / CELL CYCLE / ONCOGENIC TRANSFORMATION / ROTAMASE / SBDD / PPIASE / SMALL MOLECULE / Nucleus / Phosphoprotein |
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