EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution.
ジャーナル・号・ページ	Bioorg. Med. Chem. Lett., Vol. 20, Page 6483-, Year 2010
掲載日	2010年8月25日 (構造データの登録日)
著者	Potter, A. / Oldfield, V. / Nunns, C. / Fromont, C. / Ray, S. / Northfield, C.J. / Bryant, C.J. / Scrace, S.F. / Robinson, D. / Matossova, N. ...Potter, A. / Oldfield, V. / Nunns, C. / Fromont, C. / Ray, S. / Northfield, C.J. / Bryant, C.J. / Scrace, S.F. / Robinson, D. / Matossova, N. / Baker, L. / Dokurno, P. / Surgenor, A.E. / Davis, B. / Richardson, C.M. / Murray, J.B. / Moore, J.D.
リンク	Bioorg. Med. Chem. Lett. / PubMed:20932746
手法	X線回折
解像度	1.8 - 2.3 Å
構造データ	PDB-2xp3: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2xp4: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2xp5: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xp6: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xp7: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2xp8: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2xp9: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xpa: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2xpb: DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3odk: Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å
化合物	ChemComp-12P: DODECAETHYLENE GLYCOL / 3,6,9,12,15,18,21,24,27,30,33-ウンデカオキサペンタトリアコンタン-1,35-ジオ-ル / 沈殿剤YM ChemComp-B21: 5-(2-METHOXYPHENYL)-2-FUROIC ACID / 5-(2-メトキシフェニル)フラン-2-カルボン酸 ChemComp-HOH: WATER ChemComp-G14: 2-phenyl-1H-imidazole-4-carboxylic acid / 2-フェニル-1H-イミダゾ-ル-4-カルボン酸 ChemComp-4FF: 5-METHYL-2-PHENYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID / 2-フェニル-4-メチル-1H-イミダゾ-ル-5-カルボン酸 ChemComp-4G2: 2-(3-CHLORO-PHENYL)-5-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID ChemComp-4F8: 2-PHENYL-1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID / 2-フェニル-1H-イミダゾ-ル-4,5-ジカルボン酸 ChemComp-4FY: 4-(MORPHOLIN-4-YLCARBONYL)-2-PHENYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ChemComp-4G8: 4-[BENZYL(CARBOXYMETHYL)CARBAMOYL]-2-PHENYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ChemComp-4G5: 4-[(2-amino-2-oxoethyl)(methyl)carbamoyl]-2-phenyl-1H-imidazole-5-carboxylic acid ChemComp-4GE: 5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID ChemComp-PE4: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / ヘプタエチレングリコ-ルモノエチルエ-テル / 沈殿剤YM ChemComp-ODK: 3-pyridin-2-yl-1H-pyrazole-5-carboxylic acid
由来	homo sapiens (ヒト)
キーワード	ISOMERASE / PROLINE DIRECTED KINASE / CELL CYCLE / ONCOGENIC TRANSFORMATION / ROTAMASE / SBDD / PPIASE / SMALL MOLECULE / Nucleus / Phosphoprotein