タイトル | A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 132, Page 12711-, Year 2010 |
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掲載日 | 2010年5月14日 (構造データの登録日) |
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著者 | Zhang, A.X. / Murelli, R.P. / Barinka, C. / Michel, J. / Cocleaza, A. / Jorgensen, W.L. / Lubkowski, J. / Spiegel, D.A. |
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リンク | J. Am. Chem. Soc. / PubMed:20726553 |
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手法 | X線回折 |
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解像度 | 1.59 - 1.78 Å |
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構造データ | PDB-2xef: Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P8 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-2xeg: Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P4 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-2xei: Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P2 手法: X-RAY DIFFRACTION / 解像度: 1.69 Å PDB-2xej: Human glutamate carboxypeptidase II in complex with ARM-M4, urea- based inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å |
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化合物 | ChemComp-AR8: N-{[(1S)-5-{4-[25-({2,4-BIS[HYDROXY(OXO)AMMONIO]PHENYL}AMINO)-2,5,8,11,14,17,20,23-OCTAOXAPENTACOS-1-YL]-1H-1,2,3-TRIAZOL-1-YL}-1-CARBOXYPENTYL]CARBAMOYL}-L-GLUTAMIC ACID
ChemComp-CI9: N-({(1S)-5-[4-(13-{[2,4-BIS(DIHYDROXYAMINO)PHENYL]AMINO}-2,5,8,11-TETRAOXATRIDEC-1-YL)-1H-1,2,3-TRIAZOL-1-YL]-1-CARBOXYPENTYL}CARBAMOYL)-L-GLUTAMIC ACID
ChemComp-ARK: N-({(1S)-5-[4-({2-[2-({2,4-BIS[HYDROXY(OXO)AMMONIO]PHENYL}AMINO)ETHOXY]ETHOXY}METHYL)-1H-1,2,3-TRIAZOL-1-YL]-1-CARBOXYPENTYL}CARBAMOYL)-L-GLUTAMIC ACID
ChemComp-OKD: N-({(1S)-1-CARBOXY-5-[4-(2,5,8,11,14-PENTAOXAPENTADEC-1-YL)-1H-1,2,3-TRIAZOL-1-YL]PENTYL}CARBAMOYL)-L-GLUTAMIC ACID
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由来 | - homo sapiens (ヒト)
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キーワード | HYDROLASE / METALLOPEPTIDASE |
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