タイトル | Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34. |
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ジャーナル・号・ページ | Science, Vol. 327, Page 1638-, Year 2010 |
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掲載日 | 2010年2月17日 (構造データの登録日) |
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著者 | Miller, S. / Tavshanjian, B. / Oleksy, A. / Perisic, O. / Houseman, B.T. / Shokat, K.M. / Williams, R.L. |
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リンク | Science / PubMed:20339072 |
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手法 | X線回折 |
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解像度 | 2.9 - 3.5 Å |
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構造データ | PDB-2x6f: THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-2x6h: THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-2x6i: THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90 手法: X-RAY DIFFRACTION / 解像度: 3.4 Å PDB-2x6j: THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å PDB-2x6k: THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å |
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化合物 | ChemComp-090: N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE
ChemComp-093: N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE / PIK-93
ChemComp-X6K: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL / PI-103
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由来 | - drosophila melanogaster (キイロショウジョウバエ)
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キーワード | TRANSFERASE / PI103 / PI-103 / AUTOPHAGY / PI3K CLASS III / PHOSPHOINOSITIDE 3-KINASE CLASS III |
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