タイトル | The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 6, Page 117-, Year 2010 |
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掲載日 | 2009年11月9日 (構造データの登録日) |
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著者 | Berndt, A. / Miller, S. / Williams, O. / Lee, D.D. / Houseman, B.T. / Pacold, J.I. / Gorrec, F. / Hon, W.-C. / Liu, Y. / Rommel, C. ...Berndt, A. / Miller, S. / Williams, O. / Lee, D.D. / Houseman, B.T. / Pacold, J.I. / Gorrec, F. / Hon, W.-C. / Liu, Y. / Rommel, C. / Gaillard, P. / Ruckle, T. / Schwarz, M.K. / Shokat, K.M. / Shaw, J.P. / Williams, R.L. |
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リンク | Nat. Chem. Biol. / PubMed:20081827 |
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手法 | X線回折 |
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解像度 | 1.9 - 2.9 Å |
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構造データ | PDB-2wxf: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39. 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2wxg: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13. 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-2wxh: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14. 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2wxi: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30. 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2wxj: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654. 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-2wxk: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666. 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-2wxl: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474. 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å PDB-2wxm: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06. 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2wxn: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07. 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-2wxo: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5. 手法: X-RAY DIFFRACTION / 解像度: 2.49 Å PDB-2wxp: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941. 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2wxq: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15. 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-2wxr: The crystal structure of the murine class IA PI 3-kinase p110delta. 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2x38: The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114. 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-039: 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
ChemComp-ZZN: 2-{[4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
ChemComp-ZZO: 2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
ChemComp-S30: 2-{[4-amino-3-(3-hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
ChemComp-RW3: N-[6-(4-amino-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzothiazol-2-yl]acetamide
ChemComp-RW4: 3-(2-amino-1,3-benzothiazol-6-yl)-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine
ChemComp-ZS4: 2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1H-benzimidazole / ZSTK-474
ChemComp-ZZM: 1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
ChemComp-DLN: 3-{[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]ethynyl}phenol
ChemComp-ZZP: N-(3-{[(1Z)-3,5-DIMETHOXYCYCLOHEXA-2,4-DIEN-1-YLIDENE]AMINO}QUINOXALIN-2-YL)-4-FLUOROBENZENESULFONAMIDE
ChemComp-GD9: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine / GDC-0941
ChemComp-ZZQ: 2-{[3-(2-METHOXYPHENYL)-4-OXO-3,4,5,6,7,8-HEXAHYDROQUINAZOLIN-2-YL]SULFANYL}-N-QUINOXALIN-6-YLACETAMIDE
ChemComp-IC8: 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE / IC-87114
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由来 | ![](img/tx_mammal.gif) mus musculus (ハツカネズミ)
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キーワード | TRANSFERASE / PHOSPHOPROTEIN / ISOFORM-SPECIFIC INHIBITORS / CANCER / NUCLEOTIDE-BINDING / PHOSPHOINOSITIDE 3-KINASE |
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