EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
ジャーナル・号・ページ	J. Med. Chem., Vol. 52, Page 4794-, Year 2009
掲載日	2009年5月8日 (構造データの登録日)
著者	Brough, P.A. / Barril, X. / Borgognoni, J. / Chene, P. / Davies, N.G.M. / Davis, B. / Drysdale, M.J. / Dymock, B. / Eccles, S.A. / Garcia-Echeverria, C. ...Brough, P.A. / Barril, X. / Borgognoni, J. / Chene, P. / Davies, N.G.M. / Davis, B. / Drysdale, M.J. / Dymock, B. / Eccles, S.A. / Garcia-Echeverria, C. / Fromont, C. / Hayes, A. / Hubbard, R.E. / Jordan, A.M. / Jensen, M.R. / Massey, A. / Merrett, A. / Padfield, A. / Parsons, R. / Radimerski, T. / Raynaud, F.I. / Robertson, A. / Roughley, S.D. / Schoepfer, J. / Simmonite, H. / Sharp, S.Y. / Surgenor, A. / Valenti, M. / Walls, S. / Webb, P. / Wood, M. / Workman, P. / Wright, L.M.
リンク	J. Med. Chem. / PubMed:19610616
手法	X線回折
解像度	1.9 - 2.5 Å
構造データ	PDB-2wi1: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2wi2: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-2wi3: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2wi4: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2wi5: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2wi6: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-2wi7: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-ZZ2: 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine / 4-メチル-6-(2-メトキシエトキシ)ピリミジン-2-アミン ChemComp-HOH: WATER ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-ZZ3: 4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE / 4-メチル-6-(メチルチオ)-1,3,5-トリアジン-2-アミン ChemComp-ZZ4: 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine ChemComp-ZZ5: 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE ChemComp-ZZ6: 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE ChemComp-2KL*: 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
由来	homo sapiens (ヒト)
キーワード	CHAPERONE / PU3 / HSP90 / ATPASE / HEAT SHOCK / STRESS RESPONSE / NUCLEOTIDE-BINDING / ATP-BINDING / PHOSPHOPROTEIN / PHOSPHORYLATION