EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 52, Page 379-, Year 2009
掲載日	2008年10月17日 (構造データの登録日)
著者	Howard, S. / Berdini, V. / Boulstridge, J.A. / Carr, M.G. / Cross, D.M. / Curry, J. / Devine, L.A. / Early, T.R. / Fazal, L. / Gill, A.L. ...Howard, S. / Berdini, V. / Boulstridge, J.A. / Carr, M.G. / Cross, D.M. / Curry, J. / Devine, L.A. / Early, T.R. / Fazal, L. / Gill, A.L. / Heathcote, M. / Maman, S. / Matthews, J.E. / Mcmenamin, R.L. / Navarro, E.F. / O'Brien, M.A. / O'Reilly, M. / Rees, D.C. / Reule, M. / Tisi, D. / Williams, G. / Vinkovic, M. / Wyatt, P.G.
リンク	J. Med. Chem. / PubMed:19143567
手法	X線回折
解像度	2.15 - 3.24 Å
構造データ	PDB-2w1c: Structure determination of Aurora Kinase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.24 Å PDB-2w1d: Structure determination of Aurora Kinase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.97 Å PDB-2w1e: Structure determination of Aurora Kinase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.93 Å PDB-2w1f: Structure determination of Aurora Kinase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-2w1g: Structure determination of Aurora Kinase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.71 Å PDB-2w1h: Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-2w1i: Structure determination of Aurora Kinase in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å
化合物	ChemComp-L0C: 4-{[2-(4-{[(4-FLUOROPHENYL)CARBONYL]AMINO}-1H-PYRAZOL-3-YL)-1H-BENZIMIDAZOL-6-YL]METHYL}MORPHOLIN-4-IUM ChemComp-L0D: 2-(1H-pyrazol-3-yl)-1H-benzimidazole ChemComp-L0E: 4-[(2-{4-[(PHENYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-5-YL)METHYL]MORPHOLIN-4-IUM ChemComp-HOH: WATER ChemComp-L0F: N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE ChemComp-L0G: 2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-6-(MORPHOLIN-4-IUM-4-YLMETHYL)-1H-3,1-BENZIMIDAZOL-3-IUM ChemComp-L0I: 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / CANCER / AURORA / KINASE / INHIBITOR / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / POLYMORPHISM / PHOSPHOPROTEIN / CELL CYCLE / STRUCTURE BASED DRUG DESIGN / MITOSIS / CELL DIVISION / FRAGMENT SCREENING / CHROMOSOMAL REARRANGEMENT / TYROSINE-PROTEIN KINASE / PROTO-ONCOGENE / DISEASE MUTATION / SH2 DOMAIN / MEMBRANE