EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
ジャーナル・号・ページ	J. Med. Chem., Vol. 51, Page 183-, Year 2008
掲載日	2007年12月5日 (構造データの登録日)
著者	Frederickson, M. / Callaghan, O. / Chessari, G. / Congreve, M. / Cowan, S.R. / Matthews, J.E. / Mcmenamin, R. / Smith, D. / Vinkovic, M. / Wallis, N.G.
リンク	J. Med. Chem. / PubMed:18163548
手法	X線回折
解像度	1.72 - 2.05 Å
構造データ	PDB-2vin: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2vio: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2vip: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-2viq: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-2viv: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-2viw: Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å
化合物	ChemComp-ACT: ACETATE ION / 酢酸イオン ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-505: (2R)-1-(2,6-dimethylphenoxy)propan-2-amine / (R)-メキシレチン ChemComp-HOH: WATER ChemComp-L1O: 4-(2-aminoethoxy)-3,5-dichlorobenzoic acid ChemComp-L1R: 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE ChemComp-D55: 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide ChemComp-VG2: 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide ChemComp-D56: 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / PLASMINOGEN ACTIVATION / EGF-LIKE DOMAIN / BLOOD COAGULATION / INHIBITOR / POLYMORPHISM / GLYCOPROTEIN / FIBRINOLYSIS / KRINGLE / ZYMOGEN / SECRETED / PROTEASE / UROKINASE-TYPE PLASMINOGEN ACTIVATOR / PHARMACEUTICAL / SERINE PROTEASE / PHOSPHORYLATION