EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
ジャーナル・号・ページ	Bioorg. Med. Chem. Lett., Vol. 18, Page 66-, Year 2008
掲載日	2007年10月27日 (構造データの登録日)
著者	Douty, B. / Wayland, B. / Ala, P.J. / Bower, M.J. / Pruitt, J. / Bostrom, L. / Wei, M. / Klabe, R. / Gonneville, L. / Wynn, R. ...Douty, B. / Wayland, B. / Ala, P.J. / Bower, M.J. / Pruitt, J. / Bostrom, L. / Wei, M. / Klabe, R. / Gonneville, L. / Wynn, R. / Burn, T.C. / Liu, P.C.C. / Combs, A.P. / Yue, E.W.
リンク	Bioorg. Med. Chem. Lett. / PubMed:18037290
手法	X線回折
解像度	1.8 - 2.4 Å
構造データ	PDB-2veu: Crystal structure of protein tyrosine phosphatase 1B in complex with an isothiazolidinone-containing inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2vev: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2vew: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2vex: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2vey: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
化合物	ChemComp-IZ1: N-[(1S)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-(4-phenyl-1H-imidazol-2-yl)ethyl]-3-(trifluoromethyl)benzenesulfonamide ChemComp-HOH: WATER ChemComp-IZ2: N-[(1S)-1-(4-benzyl-1H-imidazol-2-yl)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}ethyl]-3-(trifluoromethyl)benzenesulfonamide ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-IZ3: 3-fluoro-N-[(1S)-1-[4-[(2-fluorophenyl)methyl]imidazol-2-yl]-2-[4-[(5S)-1,1,3-trioxo-1,2-thiazolidin-5-yl]phenyl]ethyl]benzenesulfonamide ChemComp-IZ4: N-{(1S)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-[(4R)-4-(2-phenylethyl)-4,5-dihydro-1H-imidazol-2-yl]ethyl}-3-fluorobenzenesulfonamide ChemComp-IZ5: N-{(1S)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-[4-(3-phenylpropyl)-1H-imidazol-2-yl]ethyl}-3-fluorobenzenesulfonamide
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / MEMBRANE / OXIDATION / ACETYLATION / PHOSPHATASE / POLYMORPHISM / PHOSPHORYLATION / PROTEIN PHOSPHATASE / ENDOPLASMIC RETICULUM