EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.
ジャーナル・号・ページ	Bioorg. Med. Chem. Lett., Vol. 17, Page 3880-, Year 2007
掲載日	2007年4月27日 (構造データの登録日)
著者	Richardson, C.M. / Nunns, C.L. / Williamson, D.S. / Parratt, M.J. / Dokurno, P. / Howes, R. / Borgognoni, J. / Drysdale, M.J. / Finch, H. / Hubbard, R.E. ...Richardson, C.M. / Nunns, C.L. / Williamson, D.S. / Parratt, M.J. / Dokurno, P. / Howes, R. / Borgognoni, J. / Drysdale, M.J. / Finch, H. / Hubbard, R.E. / Jackson, P.S. / Kierstan, P. / Lentzen, G. / Moore, J.D. / Murray, J.B. / Simmonite, H. / Surgenor, A.E. / Torrance, C.J.
リンク	Bioorg. Med. Chem. Lett. / PubMed:17570665
手法	X線回折
解像度	2.2 - 2.72 Å
構造データ	PDB-2uzb: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-2uzd: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-2uze: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2uzl: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2uzn: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2uzo: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2v0d: Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
化合物	ChemComp-C75: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE ChemComp-HOH: WATER ChemComp-C85: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE ChemComp-C95: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID ChemComp-C94: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE ChemComp-C96: 4-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDE ChemComp-C62: 4-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE ChemComp-C53: 2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE ChemComp-CL: Unknown entry / クロリド
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / ATP-BINDING / PHOSPHORYLATION / CDK2 / KINASE / CYCLIN / MITOSIS / CELL CYCLE / CELL DIVISION / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / THIAZOLIDINONE LIGAND / NUCLEOTIDE- BINDING