EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
ジャーナル・号・ページ	Structure, Vol. 16, Page 82-92, Year 2008
掲載日	2007年6月19日 (構造データの登録日)
著者	Wittmann, J.G. / Heinrich, D. / Gasow, K. / Frey, A. / Diederichsen, U. / Rudolph, M.G.
リンク	Structure / PubMed:18184586
手法	X線回折
解像度	1.22 - 2.03 Å
構造データ	PDB-2qcc: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase, apo form 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-2qcd: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP 手法: X-RAY DIFFRACTION / 解像度: 2.03 Å PDB-2qce: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to sulfate, glycerol, and chloride 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-2qcf: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 5-fluoro-UMP 手法: X-RAY DIFFRACTION / 解像度: 1.22 Å PDB-2qcg: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-bromo-UMP 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-2qch: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-iodo-UMP 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-2qcl: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to OMP 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-2qcm: Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å PDB-2qcn: Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase with 6-iodo-UMP 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-HOH: WATER ChemComp-U5P: URIDINE-5'-MONOPHOSPHATE / UMP ChemComp-CL: Unknown entry / クロリド ChemComp-5FU: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE / 5-フルオロ-5′-ウリジル酸 ChemComp-5BU: 5-BROMO-URIDINE-5'-MONOPHOSPHATE / 5-ブロモ-5′-ウリジル酸 ChemComp-IOD: IODIDE ION / ヨ-ジド ChemComp-5IU: 5-IODO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE / 5-I-dUMP ChemComp-UMP: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE / dUMP ChemComp-OMP: OROTIDINE-5'-MONOPHOSPHATE / オロチジン5′-りん酸 ChemComp-JW5: 6-(HYDROXYMETHYL)URIDINE 5'-(DIHYDROGEN PHOSPHATE)
由来	homo sapiens (ヒト)
キーワード	LYASE / UMP synthase / decarboxylase / TIM barrel / catalytic proficiency / Disease mutation / Glycosyltransferase / Multifunctional enzyme / Pyrimidine biosynthesis / Transferase