EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors
ジャーナル・号・ページ	J. Med. Chem., Vol. 50, Page 1146-1157, Year 2007
掲載日	2007年2月4日 (構造データの登録日)
著者	Davey, D.D. / Adler, M. / Arnaiz, D. / Eagen, K. / Erickson, S. / Guilford, W. / Kenrick, M. / Morrissey, M.M. / Ohlmeyer, M. / Pan, G. ...Davey, D.D. / Adler, M. / Arnaiz, D. / Eagen, K. / Erickson, S. / Guilford, W. / Kenrick, M. / Morrissey, M.M. / Ohlmeyer, M. / Pan, G. / Paradkar, V.M. / Parkinson, J. / Polokoff, M. / Saionz, K. / Santos, C. / Subramanyam, B. / Vergona, R. / Wei, R.G. / Whitlow, M. / Ye, B. / Zhao, Z.S. / Devlin, J.J. / Phillips, G.
リンク	J. Med. Chem. / PubMed:17315988
手法	X線回折
解像度	1.87 - 2.1 Å
構造データ	PDB-2oro: Murine inducible nitric oxide synthase oxygenase domain (delta 114) (r)-1-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-pyrrolidine-2-carboxylic acid (2-benzo[1,3]dioxol-5-yl-ethyl)-amide complex 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2orp: Murine inducible nitric oxide synthase oxygenase domain (delta 114) 2-[4-(2-Imidazol-1-yl-6-methyl-pyrimidin-4-yl)-1-isobutyryl-piperazin-2-yl]-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide complex 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-2orq: Murine Inducible Nitric Oxide Synthase Oxygenase Domain (DELTA 114) 4-(imidazol-1-yl)phenol and piperonylamine Complex 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2orr: Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]dioxol-5-yloxy)-2-(4-imidazol-1-yl-phenoxy)-pyrimidine Complex 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2ors: Murine Inducible Nitric Oxide Synthase Oxygenase Domain (DELTA 114) 4-(Benzo[1,3]dioxol-5-yloxy)-2-(4-imidazol-1-yl-phenoxy)-6-methyl-pyrimidine Complex 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2ort: Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 1-Benzo[1,3]dioxol-5-ylmethyl-3S-(4-imidazol-1-yl-phenoxy)-piperidine Complex 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å
化合物	ChemComp-SO3: SULFITE ION / 亜硫酸アニオン ChemComp-HEM: PROTOPORPHYRIN IX CONTAINING FE ChemComp-228: N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE ChemComp-HOH: WATER ChemComp-R86: 2-{(2R)-4-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-1-ISOBUTYRYLPIPERAZIN-2-YL}-N-[2-(4-METHOXYPHENYL)ETHYL]ACETAMIDE ChemComp-MSR: 4-(1H-IMIDAZOL-1-YL)PHENOL / 4-(1H-イミダゾ-ル-1-イル)フェノ-ル ChemComp-MR1: 1-(1,3-BENZODIOXOL-5-YL)METHANAMINE / 1,3-ベンゾジオキソ-ル-5-メタンアミン ChemComp-333: 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-391: 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ChemComp-342: (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE
由来	mus musculus (ハツカネズミ)
キーワード	OXIDOREDUCTASE / NITRIC OXIDE; L-ARGININE MONOOXYGENASE; HEME; DIMERIZATION; INHIBITOR; NOS / NITRIC OXIDE / L-ARGININE MONOOXYGENASE / HEME / DIMERIZATION / INHIBITOR / NOS