タイトル | Neighboring group participation in the transition state of human purine nucleoside phosphorylase. |
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ジャーナル・号・ページ | Biochemistry, Vol. 46, Page 5038-5049, Year 2007 |
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掲載日 | 2005年6月17日 (構造データの登録日) |
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著者 | Murkin, A.S. / Birck, M.R. / Rinaldo-Matthis, A. / Shi, W. / Taylor, E.A. / Almo, S.C. / Schramm, V.L. |
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リンク | Biochemistry / PubMed:17407325 |
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手法 | X線回折 |
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解像度 | 2.28 - 2.592 Å |
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構造データ | PDB-2a0w: Structure of human purine nucleoside phosphorylase H257G mutant 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-2a0x: Structure of human purine nucleoside phosphorylase H257F mutant 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-2a0y: Structure of human purine nucleoside phosphorylase H257D mutant 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-2oc4: Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H 手法: X-RAY DIFFRACTION / 解像度: 2.592 Å PDB-2oc9: Crystal structure of human purine nucleoside phosphorylase mutant H257G with Imm-H 手法: X-RAY DIFFRACTION / 解像度: 2.59 Å PDB-2on6: Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H 手法: X-RAY DIFFRACTION / 解像度: 2.503 Å |
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化合物 | ChemComp-DIH: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
ChemComp-IMH: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL / インムシリンH / 阻害剤*YM
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / purine nucleoside phosphorylase / transition state inhibitor / mutant |
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