タイトル | Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 50, Page 641-662, Year 2007 |
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掲載日 | 2006年11月29日 (構造データの登録日) |
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著者 | Bruncko, M. / Oost, T.K. / Belli, B.A. / Ding, H. / Joseph, M.K. / Kunzer, A. / Martineau, D. / McClellan, W.J. / Mitten, M. / Ng, S.C. ...Bruncko, M. / Oost, T.K. / Belli, B.A. / Ding, H. / Joseph, M.K. / Kunzer, A. / Martineau, D. / McClellan, W.J. / Mitten, M. / Ng, S.C. / Nimmer, P.M. / Oltersdorf, T. / Park, C.M. / Petros, A.M. / Shoemaker, A.R. / Song, X. / Wang, X. / Wendt, M.D. / Zhang, H. / Fesik, S.W. / Rosenberg, S.H. / Elmore, S.W. |
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リンク | J. Med. Chem. / PubMed:17256834 |
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手法 | NMR (溶液) |
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構造データ | PDB-2o1y: Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand 手法: SOLUTION NMR PDB-2o21: Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand 手法: SOLUTION NMR PDB-2o22: Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand 手法: SOLUTION NMR PDB-2o2f: Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand 手法: SOLUTION NMR PDB-2o2m: Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand 手法: SOLUTION NMR PDB-2o2n: Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand 手法: SOLUTION NMR |
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化合物 | ChemComp-43B: 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
ChemComp-LIU: N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide
ChemComp-LI0: 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
ChemComp-LIW: 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
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由来 | - homo sapiens (ヒト)
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キーワード | APOPTOSIS / complex / bcl |
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