タイトル | Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase. |
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ジャーナル・号・ページ | J. Biol. Chem., Vol. 282, Page 13033-13046, Year 2007 |
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掲載日 | 2005年9月15日 (構造データの登録日) |
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著者 | Xu, L. / Chong, Y. / Hwang, I. / D'Onofrio, A. / Amore, K. / Beardsley, G.P. / Li, C. / Olson, A.J. / Boger, D.L. / Wilson, I.A. |
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リンク | J. Biol. Chem. / PubMed:17324932 |
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手法 | X線回折 |
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解像度 | 2.02 - 2.9 Å |
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構造データ | PDB-2b1g: Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2b1i: crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-2iu0: crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å PDB-2iu3: Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å |
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化合物 | ChemComp-13A: 7-(3,4-DIHYDROXY-5R-HYDROXYMETHYLTETRAHYDROFURAN-2-YL)-2,2-DIOXO-1,2R,3R,7-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-4S-ONE
ChemComp-93A: [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
ChemComp-203: 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE / 1,7-ジヒドロイミダゾ[4,5-c][1,2,6]チアジアジン-4(3H)-オン2,2-ジオキシド
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由来 | - gallus gallus (ニワトリ)
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キーワード | TRANSFERASE / HYDROLASE / ATIC / IMPCH / structure-base / transition state analogue / inhibitor / MULTIFUNCTIONAL ENZYME / PURINE BIOSYNTHESIS |
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