EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
ジャーナル・号・ページ	Cancer Cell, Vol. 11, Page 217-, Year 2007
掲載日	2006年5月25日 (構造データの登録日)
著者	Yun, C.-H. / Boggon, T.J. / Li, Y. / Woo, S. / Greulich, H. / Meyerson, M. / Eck, M.J.
リンク	Cancer Cell / PubMed:17349580
手法	X線回折
解像度	2.47 - 3.42 Å
構造データ	PDB-2itn: Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 2.47 Å PDB-2ito: Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa 手法: X-RAY DIFFRACTION / 解像度: 3.25 Å PDB-2itp: Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 手法: X-RAY DIFFRACTION / 解像度: 2.74 Å PDB-2itq: Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-2itt: Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å PDB-2itu: Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2itv: Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 2.47 Å PDB-2itw: Crystal structure of EGFR kinase domain in complex with AFN941 手法: X-RAY DIFFRACTION / 解像度: 2.88 Å PDB-2itx: Crystal structure of EGFR kinase domain in complex with AMP-PNP 手法: X-RAY DIFFRACTION / 解像度: 2.98 Å PDB-2ity: Crystal structure of EGFR kinase domain in complex with Iressa 手法: X-RAY DIFFRACTION / 解像度: 3.42 Å PDB-2itz: Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2j6m: Crystal structure of EGFR kinase domain in complex with AEE788 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体YM ChemComp-HOH: WATER ChemComp-IRE: Gefitinib / ゲフィチニブ / 薬剤, 阻害剤YM ChemComp-AEE: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE / AEE-788 / 阻害剤YM ChemComp-ITQ: 1,2,3,4-Tetrahydrogen Staurosporine ChemComp-CL*: Unknown entry / クロリド
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / RECEPTOR / CELL CYCLE / ATP-BINDING / TRANSMEMBRANE / PHOSPHORYLATION / DISEASE MUTATION / POLYMORPHISM / GLYCOPROTEIN / ANTI-ONCOGENE / NUCLEOTIDE-BINDING / ALTERNATIVE SPLICING / ANP / EGFR / G719S / KINASE / AMP-PNP / MEMBRANE / TYROSINE-PROTEIN KINASE / EPIDERMAL GROWTH FACTOR / NUCLEOTIDE- BINDING / IRESSA / ZD1839 / AEE788 / AFN941 / STAUROSPORINE / L858R / MEMBRANE TYROSINE-PROTEIN KINASE / UBL CONJUGATION / WILD-TYPE