EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring
ジャーナル・号・ページ	BIOORG. MED. CHEM. LETT., Vol. 16, Page 2500-2504, Year 2006
掲載日	2006年1月20日 (構造データの登録日)
著者	Holsworth, D.D. / Cai, C. / Cheng, X.M. / Cody, W.L. / Downing, D.M. / Erasga, N. / Lee, C. / Powell, N.A. / Ednunds, J.J. / Stier, M. ...Holsworth, D.D. / Cai, C. / Cheng, X.M. / Cody, W.L. / Downing, D.M. / Erasga, N. / Lee, C. / Powell, N.A. / Ednunds, J.J. / Stier, M. / Jalaie, M. / Zhang, E. / McConnell, P. / Ryan, M.J. / Bryant, J. / Li, T. / Kasani, A. / Hall, E. / Subedi, R. / Rahim, M. / Maiti, S.
リンク	BIOORG. MED. CHEM. LETT. / PubMed:16480874
手法	X線回折
解像度	1.9 - 2.9 Å
構造データ	PDB-2fs4: Ketopiperazine-Based Renin Inhibitors: Optimization of the C ring 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2g1n: Ketopiperazine-based renin inhibitors: Optimization of the "C" ring 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-2g1o: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-2g1r: Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring 手法: X-RAY DIFFRACTION / 解像度: 2.42 Å PDB-2g1s: Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2g1y: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2g20: Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2g21: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2g22: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2g24: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2g26: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2g27: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å
化合物	ChemComp-PZ1: (6R)-6-({[1-(3-HYDROXYPROPYL)-1,7-DIHYDROQUINOLIN-7-YL]OXY}METHYL)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)PIPERAZIN-2-ONE ChemComp-HOH: WATER ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン ChemComp-1IG: N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE ChemComp-2IG: 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE ChemComp-3IG: N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE / N-[2-[6-(2,4-ジアミノ-6-エチルピリミジン-5-イル)-2,2-ジメチル-3-オキソ-3,4-ジヒドロ-(以下略) ChemComp-4IG: (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE ChemComp-5IG: 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE ChemComp-L1A: N-(MORPHOLIN-4-YLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-1,3-THIAZOL-4-YL)-N-{(1R,2R,3S)-1-[(1R)-CYCLOHEX-3-EN-1-YLMETHYL]-2,3-DIHYDROXY-5-METHYLHEXYL}-L-ALANINAMIDE ChemComp-L1B: 7-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-1-(3-METHOXYPROPYL)QUINOLINIUM ChemComp-6IG: 6-ETHYL-5-[1-(3-METHOXYPROPYL)-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]-N~4~-(2-PHENYLETHYL)PYRIMIDINE-2,4-DIAMINE ChemComp-7IG: 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE / 5-[4-(3,5-ジフルオロベンジルアミノ)フェニル]-6-エチルピリミジン-2,4-ジアミン ChemComp-3LG: (5-{[(2R)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)-6-OXOPIPERAZIN-2-YL]METHOXY}-1H-INDOL-1-YL)ACETIC ACID ChemComp-4LG: METHYL (6-{[(2R)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)-6-OXOPIPERAZIN-2-YL]METHOXY}-1H-INDOL-1-YL)ACETATE
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / protein-ligand complexes