タイトル | 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 16, Page 1574-1578, Year 2006 |
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掲載日 | 2005年11月29日 (構造データの登録日) |
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著者 | Klopfenstein, S.R. / Evdokimov, A.G. / Colson, A.-O. / Fairweather, N.T. / Neuman, J.J. / Maier, M.B. / Gray, J.L. / Gerwe, G.S. / Stake, G.E. / Howard, B.W. ...Klopfenstein, S.R. / Evdokimov, A.G. / Colson, A.-O. / Fairweather, N.T. / Neuman, J.J. / Maier, M.B. / Gray, J.L. / Gerwe, G.S. / Stake, G.E. / Howard, B.W. / Farmer, J.A. / Pokross, M.E. / Downs, T.R. / Kasibhatla, B. / Peters, K.G. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:16386905 |
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手法 | X線回折 |
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解像度 | 1.55 - 2.2 Å |
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構造データ | PDB-2f6t: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-2f6v: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-2f6w: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2f6y: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-2f6z: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-2f70: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-2f71: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å |
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化合物 | ChemComp-1C2: 3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
ChemComp-SK2: (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
ChemComp-UN3: (2-METHYL-5-PHENYL-2H-PYRAZOL-3-YL)-SULFAMIC ACID
ChemComp-ENT: 3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
ChemComp-UN5: {3(S)-METHYLCARBAMOYL-2-[3-(3-SULFOAMINO-PHENYL)-PROPIONYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-7-YL}-SULFAMIC ACID
ChemComp-UN6: (3-{[3-(3-SULFOAMINO-PHENYL)-PROPIONYLAMINO]-METHYL}-PHENYL)-SULFAMIC ACID
ChemComp-UN7: 3-[3-(3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4,-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3-OXO-PROPYL]-BENZOIC ACID
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由来 | - homo sapiens (ヒト)
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キーワード | HYDROLASE / PTP1B / sulfamic acids / tetrahydroisoquinoline / phosphatase / tyrosine |
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