タイトル | The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography. |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 2, Page 324-328, Year 2006 |
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掲載日 | 2005年11月10日 (構造データの登録日) |
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著者 | Wille, G. / Meyer, D. / Steinmetz, A. / Hinze, E. / Golbik, R. / Tittmann, K. |
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リンク | Nat. Chem. Biol. / PubMed:16680160 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.29 Å |
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構造データ | PDB-2ez4: Pyruvate oxidase variant F479W 手法: X-RAY DIFFRACTION / 解像度: 2.03 Å PDB-2ez8: Pyruvate oxidase variant F479W in complex with reaction intermediate 2-lactyl-thiamin diphosphate 手法: X-RAY DIFFRACTION / 解像度: 1.963 Å PDB-2ez9: Pyruvate oxidase variant F479W in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-2ezt: Pyruvate oxidase variant F479W in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate 手法: X-RAY DIFFRACTION / 解像度: 2.29 Å PDB-2ezu: Pyruvate oxidase variant F479W in complex with reaction intermediate 2-acetyl-thiamin diphosphate 手法: X-RAY DIFFRACTION / 解像度: 2.16 Å |
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化合物 | ChemComp-TDL: 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-CARBOXY-1-HYDROXYETHYL)-5-(2-{[HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM
ChemComp-TDK: 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM
ChemComp-TDM: 2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL
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由来 | lactobacillus plantarum (バクテリア)
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キーワード | OXIDOREDUCTASE / TPP enzyme / reaction intermediate / reaction intermediate analogue |
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