タイトル | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases |
---|
ジャーナル・号・ページ | Proc. Natl. Acad. Sci. Usa, Vol. 104, Page 10022-10027, Year 2007 |
---|
掲載日 | 2007年1月23日 (構造データの登録日) |
---|
著者 | Guo, R.T. / Cao, R. / Liang, P.H. / Ko, T.P. / Chang, T.H. / Hudock, M.P. / Jeng, W.Y. / Chen, C.K.-M. / Zhang, Y. / Song, Y. ...Guo, R.T. / Cao, R. / Liang, P.H. / Ko, T.P. / Chang, T.H. / Hudock, M.P. / Jeng, W.Y. / Chen, C.K.-M. / Zhang, Y. / Song, Y. / Kuo, C.J. / Yin, F. / Oldfield, E. / Wang, A.H.-J. |
---|
リンク | Proc. Natl. Acad. Sci. Usa / PubMed:17535895 |
---|
手法 | X線回折 |
---|
解像度 | 1.8 - 2.55 Å |
---|
構造データ | PDB-2e8t: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium, FsPP and IPP 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-2e8u: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and IPP (P21) 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-2e8v: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with product GGPP (P21) 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2e8w: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and IPP 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-2e8x: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GPP 手法: X-RAY DIFFRACTION / 解像度: 2.04 Å PDB-2e90: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium, pyrophosphate and FPP 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-2e91: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-91 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-2e92: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-261 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-2e93: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-629 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-2e94: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-364 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-2e95: S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2e98: E. coli undecaprenyl pyrophosphate synthase in complex with BPH-629 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2e99: E. coli undecaprenyl pyrophosphate synthase in complex with BPH-608 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-2e9a: E. coli undecaprenyl pyrophosphate synthase in complex with BPH-628 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2e9c: E. coli undecaprenyl pyrophosphate synthase in complex with BPH-675 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-2e9d: E. coli undecaprenyl pyrophosphate synthase in complex with BPH-676 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
---|
化合物 | ChemComp-M0N: (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID) / ミノドロン酸
ChemComp-B29: [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
ChemComp-364: 3-BIPHENYL-3-YL-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM
ChemComp-B75: 1-HYDROXY-2-[3'-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC ACID
ChemComp-B08: (1-HYDROXY-1-PHOSPHONO-2-[1,1';3',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
ChemComp-B28: (1-HYDROXY-1-PHOSPHONO-2-[1,1';4',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
ChemComp-B76: [1-HYDROXY-2-(1,1':3',1''-TERPHENYL-3-YLOXY)ETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)
|
---|
由来 | - saccharomyces cerevisiae (パン酵母)
- escherichia coli (大腸菌)
|
---|
キーワード | TRANSFERASE / prenyltransferase / farnesyl pyrophosphate / bisphosphonate / cell wall / antibiotic |
---|