タイトル | Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 16, Page 1353-, Year 2006 |
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掲載日 | 2005年11月8日 (構造データの登録日) |
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著者 | Richardson, C.M. / Williamson, D.S. / Parratt, M.J. / Borgognoni, J. / Cansfield, A.D. / Dokurno, P. / Francis, G.L. / Howes, R. / Moore, J.D. / Murray, J.B. ...Richardson, C.M. / Williamson, D.S. / Parratt, M.J. / Borgognoni, J. / Cansfield, A.D. / Dokurno, P. / Francis, G.L. / Howes, R. / Moore, J.D. / Murray, J.B. / Robertson, A. / Surgenor, A.E. / Torrance, C.J. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:16325401 |
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手法 | X線回折 |
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解像度 | 1.8 - 2.61 Å |
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構造データ | PDB-2c68: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-2c69: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2c6i: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2c6k: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2c6l: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2c6m: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2c6o: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2c6t: Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å |
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化合物 | ChemComp-CT6: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE
ChemComp-CT8: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE
ChemComp-DT1: 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
ChemComp-DT2: 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
ChemComp-DT4: 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE
ChemComp-DT5: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE (転移酵素) / SERINE/THREONINE PROTEIN KINASE / CDK2 (サイクリン依存性キナーゼ2) / ATP-BINDING / CELL CYCLE (細胞周期) / MITOSIS (有糸分裂) / PHOSPHORYLATION (リン酸化) / TRIAZOLOPYRIMIDINE INHIBITOR / CELL DIVISION (細胞分裂) / KINASE (キナーゼ) / POLYMORPHISM / NUCLEOTIDE-BINDING / COMPLEX (TRANSFERASE-CYCLIN2) |
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