タイトル | Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 48, Page 4332-, Year 2005 |
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掲載日 | 2005年4月29日 (構造データの登録日) |
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著者 | Foloppe, N. / Fisher, L.M. / Howes, R. / Kierstan, P. / Potter, A. / Robertson, A.G.S. / Surgenor, A.E. |
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リンク | J. Med. Chem. / PubMed:15974586 |
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手法 | X線回折 |
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解像度 | 2 - 2.8 Å |
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構造データ | PDB-2br1: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-2brb: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2brg: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2brh: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2brm: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2brn: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2bro: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-PFP: 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
ChemComp-PFQ: 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
ChemComp-DFY: (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
ChemComp-DFW: N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
ChemComp-DFZ: 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
ChemComp-DF1: (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
ChemComp-DF2: (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / DRUG DESIGN / FURANOPYRIMIDINE / MOLECULAR RECOGNITION / ONCOLOGY / PYRROLOPYRIMIDINE / KINASE / ATP-BINDING / CELL CYCLE / DNA DAMAGE / NUCLEAR PROTEIN / PHOSPHORYLATION / POLYMORPHISM / SERINE/THREONINE-PROTEIN KINASE |
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