タイトル | Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases. |
---|
ジャーナル・号・ページ | Structure, Vol. 12, Page 2233-2247, Year 2004 |
---|
掲載日 | 2004年9月30日 (構造データの登録日) |
---|
著者 | Card, G.L. / England, B.P. / Suzuki, Y. / Fong, D. / Powell, B. / Lee, B. / Luu, C. / Tabrizizad, M. / Gillette, S. / Ibrahim, P.N. ...Card, G.L. / England, B.P. / Suzuki, Y. / Fong, D. / Powell, B. / Lee, B. / Luu, C. / Tabrizizad, M. / Gillette, S. / Ibrahim, P.N. / Artis, D.R. / Bollag, G. / Milburn, M.V. / Kim, S.-H. / Schlessinger, J. / Zhang, K.Y.J. |
---|
リンク | Structure / PubMed:15576036 |
---|
手法 | X線回折 |
---|
解像度 | 1.37 - 2.4 Å |
---|
構造データ | PDB-1xlx: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-1xlz: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-1xm4: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-1xm6: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-1xmu: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-1xmy: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-1xn0: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-1xom: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-1xon: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-1xoq: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å PDB-1xor: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-1xos: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-1xot: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-1xoz: Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1xp0: Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å |
---|
化合物 | ChemComp-FIL: (1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME / WAY-PDA-641 / 阻害剤*YM
ChemComp-PIL: 3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE / RP-73401 / 抗炎症剤, 阻害剤*YM
ChemComp-ROF: 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE / ロフルミラスト / 薬剤, 阻害剤*YM
ChemComp-ZAR: 6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE / ザルダベリン / 抗がん剤, 阻害剤*YM
ChemComp-VIA: 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE / シルデナフィル / 薬剤*YM
ChemComp-VDN: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE / バルデナフィル / 薬剤, 阻害剤*YM
ChemComp-CIA: 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE / タダラフィル / 薬剤*YM
|
---|
由来 | - homo sapiens (ヒト)
|
---|
キーワード | HYDROLASE / PDE4B / Cilomilast / Filaminast / Piclamilast / (R)-Mesopram / Phosphodiesterase / PDE / Roflumilast / Rolipram / (R)-Rolipram / (R / S)-Rolipram / PDE4D / Zardaverine / Sildenafil / Viagra / Vardenafil / Levitra / PDE5A / Tadalafil / Cialis |
---|