タイトル | Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms |
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ジャーナル・号・ページ | Chem. Biol., Vol. 11, Page 775-, Year 2004 |
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掲載日 | 2004年3月2日 (構造データの登録日) |
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著者 | Wright, L. / Barril, X. / Dymock, B. / Sheridan, L. / Surgenor, A. / Beswick, M. / Drysdale, M. / Collier, A. / Massey, A. / Davies, N. ...Wright, L. / Barril, X. / Dymock, B. / Sheridan, L. / Surgenor, A. / Beswick, M. / Drysdale, M. / Collier, A. / Massey, A. / Davies, N. / Fink, A. / Fromont, C. / Aherne, W. / Boxall, K. / Sharp, S. / Workman, P. / Hubbard, R.E. |
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リンク | Chem. Biol. / PubMed:15217611 |
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手法 | X線回折 |
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解像度 | 1.4 - 2.45 Å |
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構造データ | PDB-1uy6: Human Hsp90-alpha with 9-Butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1uy7: Human Hsp90-alpha with 9-Butyl-8-(4-methoxy-benzyl)-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1uy8: Human Hsp90-alpha with 9-Butyl-8-(3-trimethoxy-benzyl)-9H-purin-6ylamine 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-1uy9: Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1uyc: Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1uyd: Human Hsp90-alpha with 9-Butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1uye: Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-9-pent-4-ylnyl-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1uyf: Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-2-fluoro-9-pent-4-ylnyl-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1uyg: Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1uyh: Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1uyi: Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9-pent-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1uyk: Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-2-fluoro-9H-purin-6-ylamine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1uyl: Structure-Activity Relationships in purine-based inhibitor binding to HSP90 isoforms 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-1uym: Human Hsp90-beta with PU3 (9-Butyl-8(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine) 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å |
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化合物 | |
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由来 | - homo sapiens (ヒト)
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キーワード | CHAPERONE / HSP90 / ATPASE / PU3 / ATP-BINDING / HEAT SHOCK / PU4 / PU5 / PU6 / PU7 / PU8 / PU9 / PU1 / PU2 / PU0 / PUZ / PUX |
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