EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis
ジャーナル・号・ページ	J. Med. Chem., Vol. 47, Page 2466-2474, Year 2004
掲載日	2003年11月6日 (構造データの登録日)
著者	Becker, J.W. / Rotonda, J. / Soisson, S.M. / Aspiotis, R. / Bayly, C. / Francoeur, S. / Gallant, M. / Garcia-Calvo, M. / Giroux, A. / Grimm, E. ...Becker, J.W. / Rotonda, J. / Soisson, S.M. / Aspiotis, R. / Bayly, C. / Francoeur, S. / Gallant, M. / Garcia-Calvo, M. / Giroux, A. / Grimm, E. / Han, Y. / Mckay, D. / Nicholson, D.W. / Peterson, E. / Renaud, J. / Roy, S. / Thornberry, N. / Zamboni, R.
リンク	J. Med. Chem. / PubMed:15115390
手法	X線回折
解像度	2.2 - 3 Å
構造データ	PDB-1re1: CRYSTAL STRUCTURE OF CASPASE-3 WITH A NICOTINIC ACID ALDEHYDE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1rhj: CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A PRYAZINONE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1rhk: Crystal structure of the complex of caspase-3 with a phenyl-propyl-ketone inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1rhm: CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A NICOTINIC ACID ALDEHYDE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1rhq: CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A BROMOMETHOXYPHENYL INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-1rhr: CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A CINNAMIC ACID METHYL ESTER INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-1rhu: CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A 5,6,7 TRICYCLIC PEPTIDOMIMETIC INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.51 Å
化合物	ChemComp-NA3: (3S)-3-{[(5-BROMOPYRIDIN-3-YL)CARBONYL]AMINO}-4-OXOBUTANOIC ACID / (3S)-3-(5-ブロモ-3-ピリジニルカルボニルアミノ)-4-オキソブタン酸 ChemComp-HOH: WATER ChemComp-PZN: 3-(2-{5-TERT-BUTYL-3-[(4-METHYL-FURAZAN-3-YLMETHYL)-AMINO]-2-OXO-2H-PYRAZIN-1-YL}-BUTYRYLAMINO)-5-(HEXYL-METHYL-AMINO)-4-OXO-PENTANOIC ACID ANION ChemComp-NA4: 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID ChemComp-0ZZ: 5-S-benzyl-3-({N-[(5-bromo-2-methoxyphenyl)acetyl]-L-valyl}amino)-2,3-dideoxy-5-thio-D-erythro-pentonic acid ChemComp-CNE: (3S)-5-[(2-CHLORO-6-FLUOROBENZYL)SULFANYL]-3-{[N-({2-ETHOXY-5-[(1E)-3-METHOXY-3-OXOPROP-1-ENYL]PHENYL}ACETYL)-D-VALYL]AMINO}-4-OXOPENTANOIC ACID / [N-[2-エトキシ-5-(3-オキソ-3-メトキシ-1-プロペニル)フェニルアセチル]-L-Val-L-Asp-メチ(以下略) ChemComp-3CY: (3S)-3-[({(2S)-5-[(N-ACETYL-L-ALPHA-ASPARTYL)AMINO]-4-OXO-1,2,4,5,6,7-HEXAHYDROAZEPINO[3,2,1-HI]INDOL-2-YL}CARBONYL)AMINO]-5-(BENZYLSULFANYL)-4-OXOPENTANOIC ACID
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / CYSTEINE PROTEASE / CASPASE-3 / APOPAIN / CPP32 / YAMA / COMPLEX (PROTEASE-INHIBITOR) / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX