タイトル | Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 44, Page 4339-4358, Year 2001 |
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掲載日 | 2001年11月14日 (構造データの登録日) |
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著者 | Bramson, H.N. / Corona, J. / Davis, S.T. / Dickerson, S.H. / Edelstein, M. / Frye, S.V. / Gampe Jr., R.T. / Harris, P.A. / Hassell, A. / Holmes, W.D. ...Bramson, H.N. / Corona, J. / Davis, S.T. / Dickerson, S.H. / Edelstein, M. / Frye, S.V. / Gampe Jr., R.T. / Harris, P.A. / Hassell, A. / Holmes, W.D. / Hunter, R.N. / Lackey, K.E. / Lovejoy, B. / Luzzio, M.J. / Montana, V. / Rocque, W.J. / Rusnak, D. / Shewchuk, L. / Veal, J.M. / Walker, D.H. / Kuyper, L.F. |
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リンク | J. Med. Chem. / PubMed:11728181 |
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手法 | X線回折 |
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解像度 | 2 - 2.2 Å |
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構造データ | PDB-1ke5: CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1ke6: CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1ke7: CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1ke8: CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1ke9: CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[4-({[AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-LS1: N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
ChemComp-LS2: N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE
ChemComp-LS4: 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE
ChemComp-LS5: 3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE (転移酵素) / cyclin kinase / cyclin (サイクリン) / kinase (キナーゼ) |
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