タイトル | Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. |
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ジャーナル・号・ページ | Protein Sci., Vol. 11, Page 418-429, Year 2002 |
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掲載日 | 2001年10月15日 (構造データの登録日) |
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著者 | King, N.M. / Melnick, L. / Prabu-Jeyabalan, M. / Nalivaika, E.A. / Yang, S.S. / Gao, Y. / Nie, X. / Zepp, C. / Heefner, D.L. / Schiffer, C.A. |
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リンク | Protein Sci. / PubMed:11790852 |
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手法 | X線回折 |
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解像度 | 2 - 2.25 Å |
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構造データ | PDB-1k6c: LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1k6p: LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1k6t: LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-1k6v: LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-MK1: N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY / インジナビル / 抗ウイルス剤, 抗レトロウイルス剤, プロテアーゼ阻害剤, 薬剤*YM
ChemComp-XN3: N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
ChemComp-XN1: N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4-HYDROXY-2-(1-PHENYLETHYL)-PEN
ChemComp-XN2: N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4-HYDROXY-2-(1-PHE
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由来 | - human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | HYDROLASE / INDINAVIR / INHIBITOR RECOGNITION / DRUG RESISTANCE / HIV-1 PROTEASE |
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