EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
ジャーナル・号・ページ	J. Med. Chem., Vol. 46, Page 2083-, Year 2003
掲載日	2002年8月24日 (構造データの登録日)
著者	Lenhart, A. / Reinert, D.J. / Aebi, J.D. / Dehmlow, H. / Morand, O.H. / Schulz, G.E.
リンク	J. Med. Chem. / PubMed:12747780
手法	X線回折
解像度	2.7 - 2.9 Å
構造データ	PDB-1h35: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1h36: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1h37: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1h39: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1h3a: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-1h3b: Squalene-Hopene Cyclase 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1h3c: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-1o6h: Squalene-Hopene Cyclase 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1o6q: Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-1o6r: Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-1o79: Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å
化合物	ChemComp-C8E: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE / テトラエチレングリコ-ルモノオクチルエ-テル / C8E, 可溶化剤YM ChemComp-R01: (4'-{[ALLYL(METHYL)AMINO]METHYL}-1,1'-BIPHENYL-4-YL)(4-BROMOPHENYL)METHANONE ChemComp-HOH: WATER ChemComp-R88: (4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE ChemComp-R02: {4-[((1S,2S)-2-{[ALLYL(CYCLOPROPYL)AMINO]METHYL}CYCLOPROPYL)METHOXY]PHENYL}(4-BROMOPHENYL)METHANONE ChemComp-R03: ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE ChemComp-R04: (2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE ChemComp-R46: N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE ChemComp-R79: N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE ChemComp-W37: N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE ChemComp-R17: ALLYL-{4-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-BUT-2-ENYL}-METHYL-AMINE ChemComp-R19: ALLYL-{6-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-HEXYL-}-METHYL-AMIN ChemComp-R23*: METHYL-[4-(4-PIPERIDINE-1-YLMETHYL-PHENYL)-CYCLOHEXYL]-CARBAMINIC ACID-(4-CHLOROPHENYL)-ESTER
由来	alicyclobacillus acidocaldarius (バクテリア)
キーワード	ISOMERASE / CHOLESTEROL BIOSYNTHESIS / INHIBITOR / MONOTOPIC MEMBRANE PROTEIN / INTERACTIONS / OXIDOSQUALENE CYCLASE / MONOTOPIC MEMBRANE