タイトル | Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 42, Page 1376-1383, Year 1999 |
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掲載日 | 1998年2月11日 (構造データの登録日) |
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著者 | St Charles, R. / Matthews, J.H. / Zhang, E. / Tulinsky, A. |
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リンク | J. Med. Chem. / PubMed:10212123 |
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手法 | X線回折 |
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解像度 | 2.06 - 2.2 Å |
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構造データ | PDB-1a46: THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-1a5g: HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-1a61: THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1b5g: HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å |
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化合物 | ChemComp-00K: (1S,7S)-7-amino-N-[(2R,3S)-7-amino-1-(cyclohexylamino)-2-hydroxy-1-oxoheptan-3-yl]-7-benzyl-8-oxohexahydro-1H-pyrazolo[1,2-a]pyridazine-1-carboxamide
ChemComp-00L: (1S,7S)-7-amino-7-benzyl-N-[(1S)-4-carbamimidamido-1-{(1S)-1-hydroxy-2-oxo-2-[(2-phenylethyl)amino]ethyl}butyl]-8-oxohexahydro-1H-pyrazolo[1,2-a]pyridazine-1-carboxamide
ChemComp-00N: (1S,7S)-7-amino-7-benzyl-N-{(1S)-4-carbamimidamido-1-[(S)-hydroxy(1,3-thiazol-2-yl)methyl]butyl}-8-oxohexahydro-1H-pyra
ChemComp-0ZE: [[[(4S,5S)-4-[[(3S,6S,8aR)-6-azanyl-5-oxo-6-(phenylmethyl)-1,2,3,7,8,8a-hexahydroindolizin-3-yl]carbonylamino]-5-(1,3-b
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由来 | - homo sapiens (ヒト)
- hirudo medicinalis (医用ビル)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / COMPLEX (SERINE PROTEASE-INHIBITOR) / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / SERINE PROTEASE-INHIBITOR |
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