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-Structure paper
タイトル | Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. |
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ジャーナル・号・ページ | Science, Vol. 351, Issue 6277, Page 1078-1083, Year 2016 |
掲載日 | 2016年3月4日 |
著者 | Zachary A Bornholdt / Hannah L Turner / Charles D Murin / Wen Li / Devin Sok / Colby A Souders / Ashley E Piper / Arthur Goff / Joshua D Shamblin / Suzanne E Wollen / Thomas R Sprague / Marnie L Fusco / Kathleen B J Pommert / Lisa A Cavacini / Heidi L Smith / Mark Klempner / Keith A Reimann / Eric Krauland / Tillman U Gerngross / Karl D Wittrup / Erica Ollmann Saphire / Dennis R Burton / Pamela J Glass / Andrew B Ward / Laura M Walker / |
PubMed 要旨 | Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain ...Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies. |
リンク | Science / PubMed:26912366 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 18.0 - 24.0 Å |
構造データ | EMDB-6586: EMDB-6587: EMDB-6588: EMDB-6589: |
由来 |
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