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-Structure paper
タイトル | A molecular ruler determines the repeat length in eukaryotic cilia and flagella. |
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ジャーナル・号・ページ | Science, Vol. 346, Issue 6211, Page 857-860, Year 2014 |
掲載日 | 2014年11月14日 |
著者 | Toshiyuki Oda / Haruaki Yanagisawa / Ritsu Kamiya / Masahide Kikkawa / |
PubMed 要旨 | Existence of cellular structures with specific size raises a fundamental question in biology: How do cells measure length? One conceptual answer to this question is by a molecular ruler, but examples ...Existence of cellular structures with specific size raises a fundamental question in biology: How do cells measure length? One conceptual answer to this question is by a molecular ruler, but examples of such rulers in eukaryotes are lacking. In this work, we identified a molecular ruler in eukaryotic cilia and flagella. Using cryo-electron tomography, we found that FAP59 and FAP172 form a 96-nanometer (nm)-long complex in Chlamydomonas flagella and that the absence of the complex disrupted 96-nm repeats of axonemes. Furthermore, lengthening of the FAP59/172 complex by domain duplication resulted in extension of the repeats up to 128 nm, as well as duplication of specific axonemal components. Thus, the FAP59/172 complex is the molecular ruler that determines the 96-nm repeat length and arrangements of components in cilia and flagella. |
リンク | Science / PubMed:25395538 |
手法 | EM (サブトモグラム平均) |
解像度 | 45.0 - 52.0 Å |
構造データ | EMDB-6108: EMDB-6109: EMDB-6110: EMDB-6111: EMDB-6112: EMDB-6113: EMDB-6114: EMDB-6115: EMDB-6116: EMDB-6117: |
由来 |
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