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-Structure paper
タイトル | Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3. |
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ジャーナル・号・ページ | Immunity, Vol. 55, Issue 8, Page 1501-11514.e3, Year 2022 |
掲載日 | 2022年8月9日 |
著者 | Min Huang / Lili Wu / Anqi Zheng / Yufeng Xie / Qingwen He / Xiaoyu Rong / Pu Han / Pei Du / Pengcheng Han / Zengyuan Zhang / Runchu Zhao / Yunfei Jia / Linjie Li / Bin Bai / Ziliang Hu / Shixiong Hu / Sheng Niu / Yu Hu / Honghui Liu / Bo Liu / Kaige Cui / Weiwei Li / Xin Zhao / Kefang Liu / Jianxun Qi / Qihui Wang / George Fu Gao / |
PubMed 要旨 | SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal antibodies (mAbs), covering ...SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal antibodies (mAbs), covering the seven identified epitope classes of the SARS-CoV-2 RBD, against Omicron sub-variants BA.1, BA.1.1, BA.2, and BA.3. Binding and pseudovirus-based neutralizing assays revealed that 37 of the 50 mAbs lost neutralizing activities, whereas the others displayed variably decreased activities against the four Omicron sub-variants. BA.2 was found to be more sensitive to RBD-5 antibodies than the other sub-variants. Furthermore, a quaternary complex structure of BA.1 RBD with three mAbs showing different neutralizing potencies against Omicron provided a basis for understanding the immune evasion of Omicron sub-variants and revealed the lack of G446S mutation accounting for the sensitivity of BA.2 to RBD-5 mAbs. Our results may guide the application of the available mAbs and facilitate the development of universal therapeutic antibodies and vaccines against COVID-19. |
リンク | Immunity / PubMed:35777362 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.74 Å |
構造データ | EMDB-32944, PDB-7x1m: |
由来 |
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キーワード | VIRAL PROTEIN/IMMUNE SYSTEM / antibody viral protein complex / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex |